Non-Canonical Regulation of Type I Collagen through Promoter Binding of SOX2 and Its Contribution to Ameliorating Pulmonary Fibrosis by Butylidenephthalide

Non-Canonical Regulation of Type I Collagen through Promoter Binding of SOX2 and Its Contribution to Ameliorating Pulmonary Fibrosis by Butylidenephthalide

Pulmonary fibrosis is a fatal respiratory disease that gradually leads to dyspnea, mainly accompanied by excessive collagen production in the fibroblast and myofibroblast through mechanisms such as abnormal alveolar epithelial cells remodeling and stimulation of the extracellular matrix (ECM). Our r...

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Bibliographic Details
Main Authors: Hong-Meng Chuang, Li-Ing Ho, Mao-Hsuan Huang, Kun-Lun Huang, Tzyy-Wen Chiou, Shinn-Zong Lin, Hong-Lin Su, Horng-Jyh Harn
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:International Journal of Molecular Sciences
Subjects:
pulmonary fibrosis
butylidenephthalide
SOX2
type I collagen
bleomycin
Online Access:http://www.mdpi.com/1422-0067/19/10/3024

Internet

http://www.mdpi.com/1422-0067/19/10/3024

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