H3.3K27M mutant proteins reprogram epigenome by sequestering the PRC2 complex to poised enhancers

H3.3K27M mutant proteins reprogram epigenome by sequestering the PRC2 complex to poised enhancers

Expression of histone H3.3K27M mutant proteins in human diffuse intrinsic pontine glioma (DIPG) results in a global reduction of tri-methylation of H3K27 (H3K27me3), and paradoxically, H3K27me3 peaks remain at hundreds of genomic loci, a dichotomous change that lacks mechanistic insights. Here, we s...

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Bibliographic Details
Main Authors: Dong Fang, Haiyun Gan, Liang Cheng, Jeong-Heon Lee, Hui Zhou, Jann N Sarkaria, David J Daniels, Zhiguo Zhang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-06-01
Series:eLife
Subjects:
diffuse intrinsic pontine glioma
H3.3K27M
PRC2
H3K27me3
tumor suppressor gene
WT1
Online Access:https://elifesciences.org/articles/36696

Internet

https://elifesciences.org/articles/36696

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