Repurposed Analog of GLP-1 Ameliorates Hyperglycemia in Type 1 Diabetic Mice Through Pancreatic Cell Reprogramming

Repurposed Analog of GLP-1 Ameliorates Hyperglycemia in Type 1 Diabetic Mice Through Pancreatic Cell Reprogramming

Type 1 diabetes is an autoimmune disease caused by the destruction of the insulin-producing β-cells. An ideal immunotherapy should combine the blockade of the autoimmune response with the recovery of functional target cell mass. With the aim to develop new therapies for type 1 diabetes that could co...

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Bibliographic Details
Main Authors: Adrian Villalba, Silvia Rodriguez-Fernandez, David Perna-Barrull, Rosa-Maria Ampudia, Laia Gomez-Muñoz, Irma Pujol-Autonell, Eva Aguilera, Mireia Coma, Mary Cano-Sarabia, Federico Vázquez, Joan Verdaguer, Marta Vives-Pi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Endocrinology
Subjects:
beta cell regeneration
neogenesis
transdifferentiation
liraglutide
drug repositioning
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2020.00258/full

Internet

https://www.frontiersin.org/article/10.3389/fendo.2020.00258/full

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