Neuroprotective mechanisms of ε-viniferin in a rotenone-induced cell model of Parkinson's disease: significance of SIRT3-mediated FOXO3 deacetylation

Neuroprotective mechanisms of ε-viniferin in a rotenone-induced cell model of Parkinson's disease: significance of SIRT3-mediated FOXO3 deacetylation

Trans-(-)-ε-viniferin (ε-viniferin) has antioxidative and anti-inflammatory effects. It also has neuroprotective effects in Huntington’s disease by activating the SIRT3/LKB1/AMPK signaling pathway; however, it remains unknown whether ε-viniferin also has a neuroprotective role in Parkinson’s disease...

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Bibliographic Details
Main Authors: Shuo Zhang, Yan Ma, Juan Feng
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2020-01-01
Series:Neural Regeneration Research
Subjects:
deacetylation; foxo3; mitochondrial homeostasis; mitophagy; oxidative stress; parkinson’s disease; sirt3; ε-viniferin
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2020;volume=15;issue=11;spage=2143;epage=2153;aulast=Zhang

Internet

http://www.nrronline.org/article.asp?issn=1673-5374;year=2020;volume=15;issue=11;spage=2143;epage=2153;aulast=Zhang

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