Early detection of pre-malignant lesions in a KRASG12D-driven mouse lung cancer model by monitoring circulating free DNA

Early detection of pre-malignant lesions in a KRASG12D-driven mouse lung cancer model by monitoring circulating free DNA

Lung cancer is the leading cause of cancer-related death. Two-thirds of cases are diagnosed at an advanced stage that is refractory to curative treatment. Therefore, strategies for the early detection of lung cancer are urgently sought. Total circulating free DNA (cfDNA) and tumour-derived circulati...

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Bibliographic Details
Main Authors: Callum P. Rakhit, Ricky M. Trigg, John Le Quesne, Michael Kelly, Jacqueline A. Shaw, Catrin Pritchard, L. Miguel Martins
Format: Article
Language:English
Published: The Company of Biologists 2019-02-01
Series:Disease Models & Mechanisms
Subjects:
KRASG12D
Mouse model
Circulating free DNA
cfDNA
Early detection
Lung adenocarcinoma
Online Access:http://dmm.biologists.org/content/12/2/dmm036863

Internet

http://dmm.biologists.org/content/12/2/dmm036863

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