Next Generation Sequencing Identify Rare Copy Number Variants in Non-syndromic Patent Ductus Arteriosus

Next Generation Sequencing Identify Rare Copy Number Variants in Non-syndromic Patent Ductus Arteriosus

Patent ductus arteriosus (PDA) is a common congenital cardiovascular malformation with both inherited and acquired causes. Several genes have been reported to be related to PDA, but the molecular pathogenesis is still unclear. Here, we screened a population matched cohort of 39 patients with PDA and...

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Bibliographic Details
Main Authors: Bo Chen, Aiping Hou, Lin Zhao, Ying Liu, Xin Shi, Bowen Du, Yu Yu, Pengjun Zhao, Ying Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Genetics
Subjects:
congenital heart defects
patent ductus arteriosus
whole-exome sequencing
copy number variants
pathogenesis
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2020.600787/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2020.600787/full

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