The cholesterol transporter ABCG1 modulates the subcellular distribution and proteolytic processing of β-amyloid precursor protein

The cholesterol transporter ABCG1 modulates the subcellular distribution and proteolytic processing of β-amyloid precursor protein

Although intracellular cholesterol levels are known to influence the proteolysis of β-amyloid precursor protein (APP), the effect of specific genes that regulate cholesterol metabolism on APP processing remains poorly understood. The cholesterol transporter ABCG1 facilitates cholesterol efflux to HD...

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Bibliographic Details
Main Authors: Gavin H. Tansley, Braydon L. Burgess, Matt T. Bryan, Su Yuan, Hirsch-Reinshagen Veronica, Pearce Jonathan, Jeniffer Y. Chan, Wilkinson Anna, Evans Jeanette, Kathryn E. Naus, McIsaac Sean, Bromley Kelley, Song Weihong, Yang Hsui-Chiung, Wang Nan, Ronald B. DeMattos, Cheryl L. Wellington
Format: Article
Language:English
Published: Elsevier 2007-05-01
Series:Journal of Lipid Research
Subjects:
ATP binding cassette transporter G1
Alzheimer's disease
amyloid β proteins
Down syndrome
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520435485

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http://www.sciencedirect.com/science/article/pii/S0022227520435485

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