Benzoic Acid Derivatives with Trypanocidal Activity: Enzymatic Analysis and Molecular Docking Studies toward Trans-Sialidase

Benzoic Acid Derivatives with Trypanocidal Activity: Enzymatic Analysis and Molecular Docking Studies toward Trans-Sialidase

Chagas, or American trypanosomiasis, remains an important public health problem in developing countries. In the last decade, trans-sialidase has become a pharmacological target for new anti-Chagas drugs. In this work, the aims were to design and find a new series of benzoic acid derivatives as trans...

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Bibliographic Details
Main Authors: Muhammad Kashif, Antonio Moreno-Herrera, Juan Carlos Villalobos-Rocha, Benjamín Nogueda-Torres, Jaime Pérez-Villanueva, Karen Rodríguez-Villar, José Lius Medina-Franco, Peterson de Andrade, Ivone Carvalho, Gildardo Rivera
Format: Article
Language:English
Published: MDPI AG 2017-10-01
Series:Molecules
Subjects:
benzoic acid
Chagas disease
docking
inhibitors
trans-sialidase
Online Access:https://www.mdpi.com/1420-3049/22/11/1863

Internet

https://www.mdpi.com/1420-3049/22/11/1863

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