Acid solution is a suitable medium for introducing QX-314 into nociceptors through TRPV1 channels to produce sensory-specific analgesic effects.

Acid solution is a suitable medium for introducing QX-314 into nociceptors through TRPV1 channels to produce sensory-specific analgesic effects.

BACKGROUND: Previous studies have demonstrated that QX-314, an intracellular sodium channel blocker, can enter into nociceptors through capsaicin-activated TRPV1 or permeation of the membrane by chemical enhancers to produce a sensory-selective blockade. However, the obvious side effects of these co...

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Bibliographic Details
Main Authors: He Liu, Hong-Xing Zhang, Hui-Yan Hou, Xian-Fu Lu, Jing-Qiu Wei, Chun-Guang Wang, Li-Cai Zhang, Yin-Ming Zeng, Yong-Ping Wu, Jun-Li Cao
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3247264?pdf=render

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http://europepmc.org/articles/PMC3247264?pdf=render

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