Analysis of Candida albicans mutants defective in the Cdk8 module of mediator reveal links between metabolism and biofilm formation.

Analysis of Candida albicans mutants defective in the Cdk8 module of mediator reveal links between metabolism and biofilm formation.

Candida albicans biofilm formation is a key virulence trait that involves hyphal growth and adhesin expression. Pyocyanin (PYO), a phenazine secreted by Pseudomonas aeruginosa, inhibits both C. albicans biofilm formation and development of wrinkled colonies. Using a genetic screen, we identified two...

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Bibliographic Details
Main Authors: Allia K Lindsay, Diana K Morales, Zhongle Liu, Nora Grahl, Anda Zhang, Sven D Willger, Lawrence C Myers, Deborah A Hogan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-10-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4183431?pdf=render

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http://europepmc.org/articles/PMC4183431?pdf=render

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