Initial B Cell Activation Induces Metabolic Reprogramming and Mitochondrial Remodeling

Summary: B lymphocytes provide adaptive immunity by generating antigen-specific antibodies and supporting the activation of T cells. Little is known about how global metabolism supports naive B cell activation to enable an effective immune response. By coupling RNA sequencing (RNA-seq) data with glu...

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Bibliographic Details
Main Authors: Lynnea R. Waters, Fasih M. Ahsan, Dane M. Wolf, Orian Shirihai, Michael A. Teitell
Format: Article
Language:English
Published: Elsevier 2018-07-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004218300932