Hippocampal stem cells promotes synaptic resistance to the dysfunctional impact of amyloid beta oligomers via secreted exosomes

Hippocampal stem cells promotes synaptic resistance to the dysfunctional impact of amyloid beta oligomers via secreted exosomes

Abstract Background Adult hippocampal neurogenesis plays an important role in synaptic plasticity and cogntive function. We reported that higher numbers of neural stem cells (NSC) in the hippocampus of cognitively-intact individuals with high Alzheimer’s disease (AD) pathology (plaques and tangles)...

Full description

Bibliographic Details
Main Authors: Maria-Adelaide Micci, Balaji Krishnan, Elizabeth Bishop, Wen-Ru Zhang, Jutatip Guptarak, Auston Grant, Olga Zolochevska, Batbayar Tumurbaatar, Whitney Franklin, Claudia Marino, Steven G. Widen, Arjun Luthra, Steven G. Kernie, Giulio Taglialatela
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Molecular Neurodegeneration
Subjects:
Alzheimer’s disease
Aβ oligomers
Neural stem cells
Exosomes
Synapses
Online Access:http://link.springer.com/article/10.1186/s13024-019-0322-8

Internet

http://link.springer.com/article/10.1186/s13024-019-0322-8

Similar Items