Dexamethasone induces an imbalanced fetal-placental-maternal bile acid circulation: involvement of placental transporters

Dexamethasone induces an imbalanced fetal-placental-maternal bile acid circulation: involvement of placental transporters

Abstract Background The use of prenatal dexamethasone remains controversial. Our recent studies found that prenatal dexamethasone exposure can induce maternal intrahepatic cholestasis and have a lasting adverse influence on bile acid (BA) metabolism in the offspring. The purpose of this study was to...

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Bibliographic Details
Main Authors: Wen Huang, Jin Zhou, Juanjuan Guo, Wen Hu, Guanghui Chen, Bin Li, Yajie Wen, Yimin Jiang, Kaili Fu, Huichang Bi, Yuanzhen Zhang, Hui Wang
Format: Article
Language:English
Published: BMC 2021-04-01
Series:BMC Medicine
Subjects:
Dexamethasone
Placenta
Bile acids
Transporters
Glucocorticoid receptor
Farnesoid X receptor
Online Access:https://doi.org/10.1186/s12916-021-01957-y

Internet

https://doi.org/10.1186/s12916-021-01957-y

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