Whole-exon sequencing of human myeloma cell lines shows mutations related to myeloma patients at relapse with major hits in the DNA regulation and repair pathways

Whole-exon sequencing of human myeloma cell lines shows mutations related to myeloma patients at relapse with major hits in the DNA regulation and repair pathways

Abstract Background Human myeloma cell lines (HMCLs) are widely used for their representation of primary myeloma cells because they cover patient diversity, although not fully. Their genetic background is mostly undiscovered, and no comprehensive study has ever been conducted in order to reveal thos...

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Bibliographic Details
Main Authors: Benoît Tessoulin, Agnès Moreau-Aubry, Géraldine Descamps, Patricia Gomez-Bougie, Sophie Maïga, Alban Gaignard, David Chiron, Emmanuelle Ménoret, Steven Le Gouill, Philippe Moreau, Martine Amiot, Catherine Pellat-Deceunynck
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Journal of Hematology & Oncology
Subjects:
Myelomas
WES
Tumor suppressors
DNA repair
Fanconi pathway
Online Access:http://link.springer.com/article/10.1186/s13045-018-0679-0

Internet

http://link.springer.com/article/10.1186/s13045-018-0679-0

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