Alterations in sperm DNA methylation, non-coding RNA and histone retention associate with DDT-induced epigenetic transgenerational inheritance of disease

Alterations in sperm DNA methylation, non-coding RNA and histone retention associate with DDT-induced epigenetic transgenerational inheritance of disease

Abstract Background Environmental toxicants such as DDT have been shown to induce the epigenetic transgenerational inheritance of disease (e.g., obesity) through the germline. The current study was designed to investigate the DDT-induced concurrent alterations of a number of different epigenetic pro...

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Bibliographic Details
Main Authors: Michael K. Skinner, Millissia Ben Maamar, Ingrid Sadler-Riggleman, Daniel Beck, Eric Nilsson, Margaux McBirney, Rachel Klukovich, Yeming Xie, Chong Tang, Wei Yan
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Epigenetics & Chromatin
Subjects:
Epigenetic
Transgenerational
Inheritance
Sperm
DNA methylation
ncRNA
Online Access:http://link.springer.com/article/10.1186/s13072-018-0178-0

Internet

http://link.springer.com/article/10.1186/s13072-018-0178-0

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