Gymnodimine A and 13-desMethyl Spirolide C Alter Intracellular Calcium Levels via Acetylcholine Receptors

Gymnodimine A and 13-desMethyl Spirolide C Alter Intracellular Calcium Levels via Acetylcholine Receptors

Gymnodimines and spirolides are cyclic imine phycotoxins and known antagonists of nicotinic acetylcholine receptors (nAChRs). We investigated the effect of gymnodimine A (GYM A) and 13-desmethyl spirolide C (SPX 1) from <i>Alexandrium ostenfeldii</i> on rat pheochromocytoma (PC12) cells...

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Bibliographic Details
Main Authors: Joyce A. Nieva, Bernd Krock, Urban Tillmann, Jan Tebben, Christian Zurhelle, Ulf Bickmeyer
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Toxins
Subjects:
cyclic imine
nicotinic, muscarinic, and acetylcholine receptors
calcium signaling
<i>Alexandrium ostenfeldii</i>
Online Access:https://www.mdpi.com/2072-6651/12/12/751

Internet

https://www.mdpi.com/2072-6651/12/12/751

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