Age-dependent VDR peak DNA methylation as a mechanism for latitude-dependent multiple sclerosis risk

Age-dependent VDR peak DNA methylation as a mechanism for latitude-dependent multiple sclerosis risk

Abstract Background The mechanisms linking UV radiation and vitamin D exposure to the risk of acquiring the latitude and critical period-dependent autoimmune disease, multiple sclerosis, is unclear. We examined the effect of vitamin D on DNA methylation and DNA methylation at vitamin D receptor bind...

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Bibliographic Details
Main Authors: Lawrence T. C. Ong, Stephen D. Schibeci, Nicole L. Fewings, David R. Booth, Grant P. Parnell
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Epigenetics & Chromatin
Subjects:
DNA methylation
Calcitriol
Epigenetics
Vitamin D
Myeloid
VDR binding site
Online Access:https://doi.org/10.1186/s13072-021-00383-x

Internet

https://doi.org/10.1186/s13072-021-00383-x

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