Proteomic signatures of brain regions affected by tau pathology in early and late stages of Alzheimer's disease

Proteomic signatures of brain regions affected by tau pathology in early and late stages of Alzheimer's disease

Background: Alzheimer's disease (AD) is the most common neurodegenerative disorder. Depositions of amyloid β peptide (Aβ) and tau protein are among the major pathological hallmarks of AD. Aβ and tau burden follows predictable spatial patterns during the progression of AD. Nevertheless, it remai...

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Bibliographic Details
Main Authors: Clarissa Ferolla Mendonça, Magdalena Kuras, Fábio César Sousa Nogueira, Indira Plá, Tibor Hortobágyi, László Csiba, Miklós Palkovits, Éva Renner, Péter Döme, György Marko-Varga, Gilberto B. Domont, Melinda Rezeli
Format: Article
Language:English
Published: Elsevier 2019-10-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Proteomics
Brain region vulnerability
Medial temporal lobe
Neocortex
Braak/Braak staging
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611930169X

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http://www.sciencedirect.com/science/article/pii/S096999611930169X

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