Constitutively Activated DAP12 Induces Functional Anti-Tumor Activation and Maturation of Human Monocyte-Derived DC

Constitutively Activated DAP12 Induces Functional Anti-Tumor Activation and Maturation of Human Monocyte-Derived DC

Dendritic cells (DCs) are professional antigen presenting cells with a great capacity for cross-presentation of exogenous antigens from which robust anti-tumor immune responses ensue. However, this function is not always available and requires DCs to first be primed to induce their maturation. In pa...

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Bibliographic Details
Main Authors: Robert Dalton, Alexandra Calescibetta, Jun Min Zhou, Michelle Maurin, Grace Ward, Thu Le Trinh, Nhan Tu, Danielle Gilvary, Xianghong Chen, Pingyan Cheng, Elena Kostenko, Sheng Wei, Kenneth L. Wright, Erika A. Eksioglu
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
human monocyte-derived dendritic cells
constitutively active DAP12
DC immunotherapy
Online Access:https://www.mdpi.com/1422-0067/22/3/1241

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https://www.mdpi.com/1422-0067/22/3/1241

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