4-Chloro-6-ethoxy-2-(methylthio)pyrimidine

4-Chloro-6-ethoxy-2-(methylthio)pyrimidine

4,6-Dichloro-2-(methylthio)pyrimidine (3) reacts with EtONa in EtOH, at ca. 20 °C, for 2 h, to give exclusively 4-chloro-6-ethoxy-2-(methylthio)pyrimidine (5) in 89% yield. The latter is presented as a useful multifunctionalised pyrimidine scaffold.

Bibliographic Details
Main Authors: Andreas S. Kalogirou, Panayiotis A. Koutentis
Format: Article
Language:English
Published: MDPI AG 2016-12-01
Series:Molbank
Subjects:
heterocycle
pyrimidine
multifunctionalised
Online Access:http://www.mdpi.com/1422-8599/2017/1/M923

Internet

http://www.mdpi.com/1422-8599/2017/1/M923

Similar Items