Citrate shows protective effects on cardiovascular and renal function in ischemia-induced acute kidney injury

Citrate shows protective effects on cardiovascular and renal function in ischemia-induced acute kidney injury

Abstract Background Ischemia and reperfusion (I/R) is one of the major causes of acute kidney injury (AKI). Citrate reduces hypoxia-induced mitochondrial energetic deficits in isolated proximal tubules. Moreover, citrate anticoagulation is now frequently used in renal replacement therapy. In the pre...

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Bibliographic Details
Main Authors: Anja Bienholz, Jonas Reis, Pinar Sanli, Herbert de Groot, Frank Petrat, Hana Guberina, Benjamin Wilde, Oliver Witzke, Fuat H. Saner, Andreas Kribben, Joel M. Weinberg, Thorsten Feldkamp
Format: Article
Language:English
Published: BMC 2017-04-01
Series:BMC Nephrology
Subjects:
Blood pressure
Ischemia and reperfusion
Renal clamping
Citrate
Online Access:http://link.springer.com/article/10.1186/s12882-017-0546-1

Internet

http://link.springer.com/article/10.1186/s12882-017-0546-1

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