Suplatast tosilate alleviates nasal symptoms through the suppression of nuclear factor of activated T-cells-mediated IL-9 gene expression in toluene-2,4-diisocyanate-sensitized rats

Suplatast tosilate alleviates nasal symptoms through the suppression of nuclear factor of activated T-cells-mediated IL-9 gene expression in toluene-2,4-diisocyanate-sensitized rats

Histamine H1 receptor (H1R) gene is upregulated in patients with pollinosis; its expression level is highly correlated with the nasal symptom severity. Antihistamines are widely used as allergy treatments because they inhibit histamine signaling by blocking H1R or suppressing H1R signaling as invers...

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Bibliographic Details
Main Authors: Hiroyuki Mizuguchi, Naoki Orimoto, Takuya Kadota, Takahiro Kominami, Asish K. Das, Akiho Sawada, Misaki Tamada, Kohei Miyagi, Tsubasa Adachi, Mayumi Matsumoto, Tomoya Kosaka, Yoshiaki Kitamura, Noriaki Takeda, Hiroyuki Fukui
Format: Article
Language:English
Published: Elsevier 2016-03-01
Series:Journal of Pharmacological Sciences
Subjects:
Antihistamines
Calcineurin/NFAT signaling
Combination therapy
PKCδ signaling
Suplatast tosilate
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861315002558

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http://www.sciencedirect.com/science/article/pii/S1347861315002558

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