Sunitinib Treatment for Advanced Paraganglioma: Case Report of a Novel SDHD Gene Mutation Variant and Systematic Review of the Literature

Sunitinib Treatment for Advanced Paraganglioma: Case Report of a Novel SDHD Gene Mutation Variant and Systematic Review of the Literature

BackgroundParagangliomas (PGLs) are neuroendocrine neoplasms arising from chromaffin cells of sympathetic or parasympathetic paraganglia. Systemic therapies have been used only in metastatic PGLs. Antiangiogenic agents, such as sunitinib, could be a viable therapeutic choice in the subgroup of patie...

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Bibliographic Details
Main Authors: Franz Sesti, Tiziana Feola, Giulia Puliani, Roberta Centello, Valentina Di Vito, Oreste Bagni, Andrea Lenzi, Andrea M. Isidori, Vito Cantisani, Antongiulio Faggiano, Elisa Giannetta
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Oncology
Subjects:
sunitinib
paraganglioma
Familial Paraganglioma Syndrome
succinate dehydrogenase
SDHD
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.677983/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.677983/full

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