Ex vivo model of epilepsy in organotypic slices—a new tool for drug screening

Ex vivo model of epilepsy in organotypic slices—a new tool for drug screening

Abstract Background Epilepsy is a prevalent neurological disorder worldwide. It is characterized by an enduring predisposition to generate seizures and its development is accompanied by alterations in many cellular processes. Organotypic slice cultures represent a multicellular environment with the...

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Bibliographic Details
Main Authors: Daniela M. Magalhães, Noémia Pereira, Diogo M. Rombo, Cláudia Beltrão-Cavacas, Ana M. Sebastião, Cláudia A. Valente
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Journal of Neuroinflammation
Subjects:
Epilepsy
Organotypic slice cultures
Neuroinflammation
Gliosis
Proinflammatory cytokines
Interleukin-1β
Online Access:http://link.springer.com/article/10.1186/s12974-018-1225-2

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http://link.springer.com/article/10.1186/s12974-018-1225-2

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