Role of miR-34a-5p in Hematopoietic Progenitor Cells Proliferation and Fate Decision: Novel Insights into the Pathogenesis of Primary Myelofibrosis

Role of miR-34a-5p in Hematopoietic Progenitor Cells Proliferation and Fate Decision: Novel Insights into the Pathogenesis of Primary Myelofibrosis

Primary Myelofibrosis (PMF) is a chronic Philadelphia-negative myeloproliferative neoplasm characterized by a skewed megakaryopoiesis and an overproduction of proinflammatory and profibrotic mediators that lead to the development of bone marrow (BM) fibrosis. Since we recently uncovered the upregula...

Full description

Bibliographic Details
Main Authors: Elisa Bianchi, Samantha Ruberti, Sebastiano Rontauroli, Paola Guglielmelli, Simona Salati, Chiara Rossi, Roberta Zini, Enrico Tagliafico, Alessandro Maria Vannucchi, Rossella Manfredini
Format: Article
Language:English
Published: MDPI AG 2017-01-01
Series:International Journal of Molecular Sciences
Subjects:
miR-34a-5p
nuclear receptor subfamily 4, group A, member 2 (NR4A2)
lymphoid enhancer-binding factor 1 (LEF1)
MYB
hematopoetic progenitor cells
hematopoietic differentiation
megakaryopoiesis
primary myelofibrosis
myeloproliferative neoplasms
macrophage
Online Access:http://www.mdpi.com/1422-0067/18/1/145

Internet

http://www.mdpi.com/1422-0067/18/1/145

Similar Items