Sensitivity, specificity, inclusivity and exclusivity of the updated Aptima Combo 2 assay, which provides detection coverage of the new diagnostic-escape Chlamydia trachomatis variants

Sensitivity, specificity, inclusivity and exclusivity of the updated Aptima Combo 2 assay, which provides detection coverage of the new diagnostic-escape Chlamydia trachomatis variants

Abstract Background Four new variants of Chlamydia trachomatis (nvCTs), detected in several countries, cause false-negative or equivocal results using the Aptima Combo 2 assay (AC2; Hologic). We evaluated the clinical sensitivity and specificity, as well as the analytical inclusivity and exclusivity...

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Main Authors: Magnus Unemo, Marit Hansen, Ronza Hadad, Mirja Puolakkainen, Henrik Westh, Kaisu Rantakokko-Jalava, Carina Thilesen, Michelle J. Cole, Iryna Boiko, Pham T. Lan, Daniel Golparian, Shin Ito, Martin Sundqvist
Format: Article
Language:English
Published: BMC 2020-06-01
Series:BMC Infectious Diseases
Subjects:
Finnish new variant
Chlamydia trachomatis
Aptima combo 2
23S rRNA
Validation
Surveillance
Online Access:http://link.springer.com/article/10.1186/s12879-020-05148-7

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http://link.springer.com/article/10.1186/s12879-020-05148-7

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