TRPV4 Inhibition and CRISPR-Cas9 Knockout Reduce Inflammation Induced by Hyperphysiological Stretching in Human Annulus Fibrosus Cells

TRPV4 Inhibition and CRISPR-Cas9 Knockout Reduce Inflammation Induced by Hyperphysiological Stretching in Human Annulus Fibrosus Cells

Mechanical loading and inflammation interact to cause degenerative disc disease and low back pain (LBP). However, the underlying mechanosensing and mechanotransductive pathways are poorly understood. This results in untargeted pharmacological treatments that do not take the mechanical aspect of LBP...

Full description

Bibliographic Details
Main Authors: Elena Cambria, Matthias J. E. Arlt, Sandra Wandel, Olga Krupkova, Wolfgang Hitzl, Fabian S. Passini, Oliver N. Hausmann, Jess G. Snedeker, Stephen J. Ferguson, Karin Wuertz-Kozak
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cells
Subjects:
mechanotransduction
cyclic stretching
transient receptor potential channel
gene editing
interleukins
low back pain
Online Access:https://www.mdpi.com/2073-4409/9/7/1736

Internet

https://www.mdpi.com/2073-4409/9/7/1736

Similar Items