Discordant expression of the sterol pathway in lens underlies simvastatin-induced cataracts in Chbb

Discordant expression of the sterol pathway in lens underlies simvastatin-induced cataracts in Chbb

Simvastatin rapidly induced cataracts in young Chbb:Thom (27) but not Sprague Dawley (SD) or Hilltop Wistar (HW) rats. Oral treatment for 14 but not 7 days committed CT rat lenses to cataract formation. The cholesterol to phospholipid molar ratio in lenses of treated CT rats was unchanged. Differenc...

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Bibliographic Details
Main Authors: Richard J. Cenedella, Jerome R. Kuszak, Kristin J. Al-Ghoul, Shucun Qin, Patricia S. Sexton
Format: Article
Language:English
Published: Elsevier 2003-01-01
Series:Journal of Lipid Research
Subjects:
3-hydroxy-3-methylglutaryl CoA reductase
3-hydroxy-3-methylglutaryl CoA synthase
sterol synthesis
squalene synthase
inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520328364

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http://www.sciencedirect.com/science/article/pii/S0022227520328364

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