Discordant expression of the sterol pathway in lens underlies simvastatin-induced cataracts in Chbb
Simvastatin rapidly induced cataracts in young Chbb:Thom (27) but not Sprague Dawley (SD) or Hilltop Wistar (HW) rats. Oral treatment for 14 but not 7 days committed CT rat lenses to cataract formation. The cholesterol to phospholipid molar ratio in lenses of treated CT rats was unchanged. Differenc...
Main Authors: | Richard J. Cenedella, Jerome R. Kuszak, Kristin J. Al-Ghoul, Shucun Qin, Patricia S. Sexton |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2003-01-01
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Series: | Journal of Lipid Research |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520328364 |
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