Salidroside Promotes the Pathological α-Synuclein Clearance Through Ubiquitin-Proteasome System in SH-SY5Y Cells

Salidroside Promotes the Pathological α-Synuclein Clearance Through Ubiquitin-Proteasome System in SH-SY5Y Cells

Parkinson’s disease (PD) is characterized by the loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc) and the presence of Lewy bodies (LBs) in the surviving SNc neurons. LBs formation is caused by the accumulation of α-synuclein (α-syn) or phosphorylated α-syn at serine-129...

Full description

Bibliographic Details
Main Authors: Tao Li, Yang Feng, Ruixin Yang, Leitao Wu, Ruru Li, Lu Huang, Qian Yang, Jianzong Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Pharmacology
Subjects:
Parkinson’s disease
salidroside
α-synuclein
UPS
6-OHDA
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00377/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2018.00377/full

Similar Items