Exosomes derived from bone marrow mesenchymal stem cells protect the injured spinal cord by inhibiting pericyte pyroptosis

Exosomes derived from bone marrow mesenchymal stem cells protect the injured spinal cord by inhibiting pericyte pyroptosis

Mesenchymal stem cell (MSC) transplantation is a promising treatment strategy for spinal cord injury, but immunological rejection and possible tumor formation limit its application. The therapeutic effects of MSCs mainly depend on their release of soluble paracrine factors. Exosomes are essential fo...

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Bibliographic Details
Main Authors: Yan Zhou, Lu-Lu Wen, Yan-Fei Li, Kai-Min Wu, Ran-Ran Duan, Yao-Bing Yao, Li-Jun Jing, Zhe Gong, Jun-Fang Teng, Yan-Jie Jia
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2022-01-01
Series:Neural Regeneration Research
Subjects:
blood-spinal cord barrier; edema; exosome; pericyte; nod1; pro-caspase 1; pyroptosis; spinal cord injury
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=1;spage=194;epage=202;aulast=Zhou

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=1;spage=194;epage=202;aulast=Zhou

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