The Role of Lysosomes in a Broad Disease-Modifying Approach Evaluated across Transgenic Mouse Models of Alzheimer’s Disease and Parkinson’s Disease and Models of Mild Cognitive Impairment

The Role of Lysosomes in a Broad Disease-Modifying Approach Evaluated across Transgenic Mouse Models of Alzheimer’s Disease and Parkinson’s Disease and Models of Mild Cognitive Impairment

Many neurodegenerative disorders have lysosomal impediments, and the list of proposed treatments targeting lysosomes is growing. We investigated the role of lysosomes in Alzheimer’s disease (AD) and other age-related disorders, as well as in a strategy to compensate for lysosomal disturban...

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Bibliographic Details
Main Authors: Jeannie Hwang, Candice M. Estick, Uzoma S. Ikonne, David Butler, Morgan C. Pait, Lyndsie H. Elliott, Sarah Ruiz, Kaitlan Smith, Katherine M. Rentschler, Cary Mundell, Michael F. Almeida, Nicole Stumbling Bear, James P. Locklear, Yara Abumohsen, Cecily M. Ivey, Karen L.G. Farizatto, Ben A. Bahr
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:International Journal of Molecular Sciences
Subjects:
Aβ42
age
α-synuclein
cathepsin B
PADK
synaptic repair
ZFAD
Z-Phe-Ala-CHN<sub>2</sub>
Online Access:https://www.mdpi.com/1422-0067/20/18/4432

Internet

https://www.mdpi.com/1422-0067/20/18/4432

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