Loss of amphiregulin reduces myoepithelial cell coverage of mammary ducts and alters breast tumor growth

Loss of amphiregulin reduces myoepithelial cell coverage of mammary ducts and alters breast tumor growth

Abstract Background Amphiregulin (AREG), a ligand of the epidermal growth factor receptor, is not only essential for proper mammary ductal development, but also associated with breast cancer proliferation and growth. In the absence of AREG, mammary ductal growth is stunted and fails to expand. Furth...

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Bibliographic Details
Main Authors: Serena P. H. Mao, Minji Park, Ramon M. Cabrera, John R. Christin, George S. Karagiannis, Maja H. Oktay, Dietmar M. W. Zaiss, Scott I. Abrams, Wenjun Guo, John S. Condeelis, Paraic A. Kenny, Jeffrey E. Segall
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Breast Cancer Research
Subjects:
Amphiregulin
Mammary ductal development
MMTV-PyMT
Breast cancer
Online Access:http://link.springer.com/article/10.1186/s13058-018-1057-0

Internet

http://link.springer.com/article/10.1186/s13058-018-1057-0

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