Critical Phenomena in the Temperature-Pressure-Crowding Phase Diagram of a Protein

Inside the cell, proteins fold and perform complex functions through global structural rearrangements. For proper function, they need to be at the brink of instability to be susceptible to small environmental fluctuations yet stable enough to maintain structural integrity. These apparently conflicti...

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Bibliographic Details
Main Authors: Andrei G. Gasic, Mayank M. Boob, Maxim B. Prigozhin, Dirar Homouz, Caleb M. Daugherty, Martin Gruebele, Margaret S. Cheung
Format: Article
Language:English
Published: American Physical Society 2019-11-01
Series:Physical Review X
Online Access:http://doi.org/10.1103/PhysRevX.9.041035