Break-induced replication is highly inaccurate.

DNA must be synthesized for purposes of genome duplication and DNA repair. While the former is a highly accurate process, short-patch synthesis associated with repair of DNA damage is often error-prone. Break-induced replication (BIR) is a unique cellular process that mimics normal DNA replication i...

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Bibliographic Details
Main Authors: Angela Deem, Andrea Keszthelyi, Tiffany Blackgrove, Alexandra Vayl, Barbara Coffey, Ruchi Mathur, Andrei Chabes, Anna Malkova
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-02-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC3039667?pdf=render