Vicinal difunctionalization of carbon–carbon double bond for the platform synthesis of trifluoroalkyl amines

Vicinal difunctionalization of carbon–carbon double bond for the platform synthesis of trifluoroalkyl amines

Metal-free olefin diamination may display challenges, especially when targeting fluorinated amines. Here, the authors report a double nucleophilic functionalization of an activated alkene originated from a trifluoropropenyliodonium salt with two nucleophiles for the selective synthesis of trifluorom...

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Main Authors: Ferenc Béke, Ádám Mészáros, Ágnes Tóth, Bence Béla Botlik, Zoltán Novák
Format: Article
Language:English
Published: Nature Publishing Group 2020-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-19748-z
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spelling doaj-55d08cc60c9f43458b00a6acab6f6a5e2021-01-31T13:37:08ZengNature Publishing GroupNature Communications2041-17232020-11-011111910.1038/s41467-020-19748-zVicinal difunctionalization of carbon–carbon double bond for the platform synthesis of trifluoroalkyl aminesFerenc Béke0Ádám Mészáros1Ágnes Tóth2Bence Béla Botlik3Zoltán Novák4ELTE “Lendület” Catalysis and Organic Synthesis Research Group, Institute of Chemistry, Eötvös Loránd UniversityELTE “Lendület” Catalysis and Organic Synthesis Research Group, Institute of Chemistry, Eötvös Loránd UniversityELTE “Lendület” Catalysis and Organic Synthesis Research Group, Institute of Chemistry, Eötvös Loránd UniversityELTE “Lendület” Catalysis and Organic Synthesis Research Group, Institute of Chemistry, Eötvös Loránd UniversityELTE “Lendület” Catalysis and Organic Synthesis Research Group, Institute of Chemistry, Eötvös Loránd UniversityMetal-free olefin diamination may display challenges, especially when targeting fluorinated amines. Here, the authors report a double nucleophilic functionalization of an activated alkene originated from a trifluoropropenyliodonium salt with two nucleophiles for the selective synthesis of trifluoromethylated ethylene amines and diamines.https://doi.org/10.1038/s41467-020-19748-z
collection DOAJ
language English
format Article
sources DOAJ
author Ferenc Béke
Ádám Mészáros
Ágnes Tóth
Bence Béla Botlik
Zoltán Novák
spellingShingle Ferenc Béke
Ádám Mészáros
Ágnes Tóth
Bence Béla Botlik
Zoltán Novák
Vicinal difunctionalization of carbon–carbon double bond for the platform synthesis of trifluoroalkyl amines
Nature Communications
author_facet Ferenc Béke
Ádám Mészáros
Ágnes Tóth
Bence Béla Botlik
Zoltán Novák
author_sort Ferenc Béke
title Vicinal difunctionalization of carbon–carbon double bond for the platform synthesis of trifluoroalkyl amines
title_short Vicinal difunctionalization of carbon–carbon double bond for the platform synthesis of trifluoroalkyl amines
title_full Vicinal difunctionalization of carbon–carbon double bond for the platform synthesis of trifluoroalkyl amines
title_fullStr Vicinal difunctionalization of carbon–carbon double bond for the platform synthesis of trifluoroalkyl amines
title_full_unstemmed Vicinal difunctionalization of carbon–carbon double bond for the platform synthesis of trifluoroalkyl amines
title_sort vicinal difunctionalization of carbon–carbon double bond for the platform synthesis of trifluoroalkyl amines
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-11-01
description Metal-free olefin diamination may display challenges, especially when targeting fluorinated amines. Here, the authors report a double nucleophilic functionalization of an activated alkene originated from a trifluoropropenyliodonium salt with two nucleophiles for the selective synthesis of trifluoromethylated ethylene amines and diamines.
url https://doi.org/10.1038/s41467-020-19748-z
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AT adammeszaros vicinaldifunctionalizationofcarboncarbondoublebondfortheplatformsynthesisoftrifluoroalkylamines
AT agnestoth vicinaldifunctionalizationofcarboncarbondoublebondfortheplatformsynthesisoftrifluoroalkylamines
AT bencebelabotlik vicinaldifunctionalizationofcarboncarbondoublebondfortheplatformsynthesisoftrifluoroalkylamines
AT zoltannovak vicinaldifunctionalizationofcarboncarbondoublebondfortheplatformsynthesisoftrifluoroalkylamines
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