Vicinal difunctionalization of carbon–carbon double bond for the platform synthesis of trifluoroalkyl amines
Metal-free olefin diamination may display challenges, especially when targeting fluorinated amines. Here, the authors report a double nucleophilic functionalization of an activated alkene originated from a trifluoropropenyliodonium salt with two nucleophiles for the selective synthesis of trifluorom...
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2020-11-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-020-19748-z |
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doaj-55d08cc60c9f43458b00a6acab6f6a5e2021-01-31T13:37:08ZengNature Publishing GroupNature Communications2041-17232020-11-011111910.1038/s41467-020-19748-zVicinal difunctionalization of carbon–carbon double bond for the platform synthesis of trifluoroalkyl aminesFerenc Béke0Ádám Mészáros1Ágnes Tóth2Bence Béla Botlik3Zoltán Novák4ELTE “Lendület” Catalysis and Organic Synthesis Research Group, Institute of Chemistry, Eötvös Loránd UniversityELTE “Lendület” Catalysis and Organic Synthesis Research Group, Institute of Chemistry, Eötvös Loránd UniversityELTE “Lendület” Catalysis and Organic Synthesis Research Group, Institute of Chemistry, Eötvös Loránd UniversityELTE “Lendület” Catalysis and Organic Synthesis Research Group, Institute of Chemistry, Eötvös Loránd UniversityELTE “Lendület” Catalysis and Organic Synthesis Research Group, Institute of Chemistry, Eötvös Loránd UniversityMetal-free olefin diamination may display challenges, especially when targeting fluorinated amines. Here, the authors report a double nucleophilic functionalization of an activated alkene originated from a trifluoropropenyliodonium salt with two nucleophiles for the selective synthesis of trifluoromethylated ethylene amines and diamines.https://doi.org/10.1038/s41467-020-19748-z |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ferenc Béke Ádám Mészáros Ágnes Tóth Bence Béla Botlik Zoltán Novák |
spellingShingle |
Ferenc Béke Ádám Mészáros Ágnes Tóth Bence Béla Botlik Zoltán Novák Vicinal difunctionalization of carbon–carbon double bond for the platform synthesis of trifluoroalkyl amines Nature Communications |
author_facet |
Ferenc Béke Ádám Mészáros Ágnes Tóth Bence Béla Botlik Zoltán Novák |
author_sort |
Ferenc Béke |
title |
Vicinal difunctionalization of carbon–carbon double bond for the platform synthesis of trifluoroalkyl amines |
title_short |
Vicinal difunctionalization of carbon–carbon double bond for the platform synthesis of trifluoroalkyl amines |
title_full |
Vicinal difunctionalization of carbon–carbon double bond for the platform synthesis of trifluoroalkyl amines |
title_fullStr |
Vicinal difunctionalization of carbon–carbon double bond for the platform synthesis of trifluoroalkyl amines |
title_full_unstemmed |
Vicinal difunctionalization of carbon–carbon double bond for the platform synthesis of trifluoroalkyl amines |
title_sort |
vicinal difunctionalization of carbon–carbon double bond for the platform synthesis of trifluoroalkyl amines |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2020-11-01 |
description |
Metal-free olefin diamination may display challenges, especially when targeting fluorinated amines. Here, the authors report a double nucleophilic functionalization of an activated alkene originated from a trifluoropropenyliodonium salt with two nucleophiles for the selective synthesis of trifluoromethylated ethylene amines and diamines. |
url |
https://doi.org/10.1038/s41467-020-19748-z |
work_keys_str_mv |
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1724317072187457536 |