Identification of novel DNA methylation inhibitors via a two-component reporter gene system

<p>Abstract</p> <p>Background</p> <p>Targeting abnormal DNA methylation represents a therapeutically relevant strategy for cancer treatment as demonstrated by the US Food and Drug Administration approval of the DNA methyltransferase inhibitors azacytidine and 5-aza-2�...

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Bibliographic Details
Main Authors: Chen Ching-Shih, Huang Tim HM, Tseng Min-Jen, Teng I-Wen, Hsu Chia-Chen, Wang Shi-Gang, Shaw Arthur Y, Lin Yi-Shiuan, Leu Yu-Wei, Hsiao Shu-Huei
Format: Article
Language:English
Published: BMC 2011-01-01
Series:Journal of Biomedical Science
Online Access:http://www.jbiomedsci.com/content/18/1/3