Hes1 Oscillations Contribute to Heterogeneous Differentiation Responses in Embryonic Stem Cells

Embryonic stem (ES) cells can differentiate into multiple types of cells belonging to all three germ layers. Although ES cells are clonally established, they display heterogeneous responses upon the induction of differentiation, resulting in a mixture of various types of differentiated cells. Our re...

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Bibliographic Details
Main Authors: Ryoichiro Kageyama, Taeko Kobayashi
Format: Article
Language:English
Published: MDPI AG 2011-02-01
Series:Genes
Subjects:
Online Access:http://www.mdpi.com/2073-4425/2/1/219/