High levels of dietary methionine improves sitagliptin-induced hepatotoxicity by attenuating oxidative stress in hypercholesterolemic rats

High levels of dietary methionine improves sitagliptin-induced hepatotoxicity by attenuating oxidative stress in hypercholesterolemic rats

Abstract Background Both cholesterol (Cho) and methionine (Met, a precursor for homocysteine) are risk factors for fatty liver disease. Since Western diets are rich in Cho and Met, we investigated the hepatic effects of feeding a diet enriched in Met and Cho. Further, based on the reported anti-oxid...

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Bibliographic Details
Main Authors: Avinash Kumar, Rashmi Pathak, Henry A. Palfrey, Kirsten P. Stone, Thomas W. Gettys, Subramanyam N. Murthy
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Nutrition & Metabolism
Subjects:
Methionine
Hepatotoxicity
Cholesterol
Sitagliptin
Oxidative stress
Online Access:https://doi.org/10.1186/s12986-019-0422-z

Internet

https://doi.org/10.1186/s12986-019-0422-z

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