Developing an Injectable Nanofibrous Extracellular Matrix Hydrogel With an Integrin αvβ3 Ligand to Improve Endothelial Cell Survival, Engraftment and Vascularization

Developing an Injectable Nanofibrous Extracellular Matrix Hydrogel With an Integrin αvβ3 Ligand to Improve Endothelial Cell Survival, Engraftment and Vascularization

Endothelial cell (EC) transplantation via injectable collagen hydrogel has received much attention as a potential treatment for various vascular diseases. However, the therapeutic effect of transplanted ECs is limited by their poor viability, which partially occurs as a result of cellular apoptosis...

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Bibliographic Details
Main Authors: Dake Hao, Ruiwu Liu, Kewa Gao, Chuanchao He, Siqi He, Cunyi Zhao, Gang Sun, Diana L. Farmer, Alyssa Panitch, Kit S. Lam, Aijun Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
collagen hydrogel
endothelial cell
integrin-based ligand
cell engraftment
tissue regeneration
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2020.00890/full

Internet

https://www.frontiersin.org/article/10.3389/fbioe.2020.00890/full

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