Sickle cell disease and malaria: decreased exposure and asplenia can modulate the risk from Plasmodium falciparum

Sickle cell disease and malaria: decreased exposure and asplenia can modulate the risk from Plasmodium falciparum

Abstract Background Patients with sickle cell disease (SCD), an inherited haemoglobinopathy, have increased risk of malaria, at least in part due to impaired splenic function. Infection with Plasmodium falciparum in SCD patients can trigger painful vaso-occlusive crisis, increase the severity of ana...

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Bibliographic Details
Main Authors: Richard O. Mwaiswelo, William Mawala, Per O. Iversen, Mariane de Montalembert, Lucio Luzzatto, Julie Makani
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Malaria Journal
Subjects:
Chemoprophylaxis
Malaria
Sickle cell disease
Splenic dysfunction
Splenectomy
Online Access:http://link.springer.com/article/10.1186/s12936-020-03212-w

Internet

http://link.springer.com/article/10.1186/s12936-020-03212-w

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