Dietary Copper Plays an Important Role in Maintaining Intestinal Barrier Integrity During Alcohol-Induced Liver Disease Through Regulation of the Intestinal HIF-1α Signaling Pathway and Oxidative Stress

Dietary Copper Plays an Important Role in Maintaining Intestinal Barrier Integrity During Alcohol-Induced Liver Disease Through Regulation of the Intestinal HIF-1α Signaling Pathway and Oxidative Stress

Impaired intestinal barrier function and oxidative stress injury play critical roles in the pathogenesis of alcoholic liver disease (ALD), and recent investigations have revealed a role for dietary copper in the liver and intestinal barrier function. Therefore, the current study investigates the mec...

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Bibliographic Details
Main Authors: Hongwei Lin, Dazhi Chen, Qianjing Du, Tongtong Pan, Hanxiao Tu, Yuedong Xu, Teng Teng, Jingjing Tu, Ji Li, Zhuo Lin, Xiaodong Wang, Lanman Xu, Yong-Ping Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Physiology
Subjects:
copper
HIF-1α
alcoholic liver injury
intestinal barrier
Caco-2
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00369/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2020.00369/full

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