Amniotic-fluid-derived mesenchymal stem cells overexpressing interleukin-1 receptor antagonist improve fulminant hepatic failure.

Amniotic-fluid-derived mesenchymal stem cells overexpressing interleukin-1 receptor antagonist improve fulminant hepatic failure.

Uncontrolled hepatic immunoactivation is regarded as the primary pathological mechanism of fulminant hepatic failure (FHF). The major acute-phase mediators associated with FHF, including IL-1β, IL-6, and TNF-α, impair the regeneration of liver cells and stem cell grafts. Amniotic-fluid-derived mesen...

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Bibliographic Details
Main Authors: Yu-Bao Zheng, Xiao-Hong Zhang, Zhan-Lian Huang, Chao-Shuang Lin, Jing Lai, Yu-Rong Gu, Bin-Liang Lin, Dong-Ying Xie, Shi-Bin Xie, Liang Peng, Zhi-Liang Gao
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3402415?pdf=render

Internet

http://europepmc.org/articles/PMC3402415?pdf=render

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