Contribution of brain pericytes in blood–brain barrier formation and maintenance: a transcriptomic study of cocultured human endothelial cells derived from hematopoietic stem cells

Contribution of brain pericytes in blood–brain barrier formation and maintenance: a transcriptomic study of cocultured human endothelial cells derived from hematopoietic stem cells

Abstract Formation, maintenance, and repair of the blood–brain barrier (BBB) are critical for central nervous system homeostasis. The interaction of endothelial cells (ECs) with brain pericytes is known to induce BBB characteristics in brain ECs during embryogenesis and can be used to differentiate...

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Bibliographic Details
Main Authors: Marjolein Heymans, Ricardo Figueiredo, Lucie Dehouck, David Francisco, Yasuteru Sano, Fumitaka Shimizu, Takashi Kanda, Rémy Bruggmann, Britta Engelhardt, Peter Winter, Fabien Gosselet, Maxime Culot
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Fluids and Barriers of the CNS
Subjects:
Blood–brain barrier1
Transcriptome2
BBB formation3
In vitro4
Central nervous system5
Brain endothelial cells6
Online Access:http://link.springer.com/article/10.1186/s12987-020-00208-1

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http://link.springer.com/article/10.1186/s12987-020-00208-1

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