Pharmacodynamic and pharmacokinetic profiles of a neurotensin receptor type 2 (NTS2) analgesic macrocyclic analog

Pharmacodynamic and pharmacokinetic profiles of a neurotensin receptor type 2 (NTS2) analgesic macrocyclic analog

The current opioid crisis highlights the urgent need to develop safe and effective pain medications. Thus, neurotensin (NT) compounds represent a promising approach, as the antinociceptive effects of NT are mediated by activation of the two G protein-coupled receptor subtypes (i.e., NTS1 and NTS2) a...

Full description

Bibliographic Details
Main Authors: Magali Chartier, Michael Desgagné, Marc Sousbie, Charles Rumsby, Lucie Chevillard, Léa Théroux, Lounès Haroune, Jérôme Côté, Jean-Michel Longpré, Pierre-Luc Boudreault, Éric Marsault, Philippe Sarret
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Macrocycle
Metabolic stability
Analgesia
Pain
Opioid-sparing effects
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332221006430

Internet

http://www.sciencedirect.com/science/article/pii/S0753332221006430

Similar Items