Pharmacodynamic and pharmacokinetic profiles of a neurotensin receptor type 2 (NTS2) analgesic macrocyclic analog

Pharmacodynamic and pharmacokinetic profiles of a neurotensin receptor type 2 (NTS2) analgesic macrocyclic analog

The current opioid crisis highlights the urgent need to develop safe and effective pain medications. Thus, neurotensin (NT) compounds represent a promising approach, as the antinociceptive effects of NT are mediated by activation of the two G protein-coupled receptor subtypes (i.e., NTS1 and NTS2) a...

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Bibliographic Details
Main Authors:	Magali Chartier, Michael Desgagné, Marc Sousbie, Charles Rumsby, Lucie Chevillard, Léa Théroux, Lounès Haroune, Jérôme Côté, Jean-Michel Longpré, Pierre-Luc Boudreault, Éric Marsault, Philippe Sarret
Format:	Article
Language:	English
Published:	Elsevier 2021-09-01
Series:	Biomedicine & Pharmacotherapy
Subjects:	Macrocycle Metabolic stability Analgesia Pain Opioid-sparing effects
Online Access:	http://www.sciencedirect.com/science/article/pii/S0753332221006430

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