Self-assembled angiopep-2 modified lipid-poly (hypoxic radiosensitized polyprodrug) nanoparticles delivery TMZ for glioma synergistic TMZ and RT therapy

Self-assembled angiopep-2 modified lipid-poly (hypoxic radiosensitized polyprodrug) nanoparticles delivery TMZ for glioma synergistic TMZ and RT therapy

The addition of temozolomide (TMZ) to radiotherapy (RT) improves survival of patients with glioblastoma (GBM). However, TMZ + RT causes excess toxicity in patients. In this study, we prepared angiopep-2 (A2) modified lipid-poly (hypoxic radiosensitized polyprodrug) nanoparticles for TMZ delivery (A2...

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Bibliographic Details
Main Authors: Zhenkun Zong, Lei Hua, Zhen Wang, Haoyue Xu, Chengkun Ye, Bomin Pan, Zongren Zhao, Longzhen Zhang, Jun Lu, Hongmei Liu, Rutong Yu
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Drug Delivery
Subjects:
glioma
angiopep-2
radiosensitized polyprodrug
tmz
synergetic therapy
Online Access:http://dx.doi.org/10.1080/10717544.2018.1534897

Internet

http://dx.doi.org/10.1080/10717544.2018.1534897

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