Enhancing the Mitochondrial Uptake of Phosphonium Cations by Carboxylic Acid Incorporation

Enhancing the Mitochondrial Uptake of Phosphonium Cations by Carboxylic Acid Incorporation

There is considerable interest in developing drugs and probes targeted to mitochondria in order to understand and treat the many pathologies associated with mitochondrial dysfunction. The large membrane potential, negative inside, across the mitochondrial inner membrane enables delivery of molecules...

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Bibliographic Details
Main Authors: Laura Pala, Hans M. Senn, Stuart T. Caldwell, Tracy A. Prime, Stefan Warrington, Thomas P. Bright, Hiran A. Prag, Claire Wilson, Michael P. Murphy, Richard C. Hartley
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Chemistry
Subjects:
mitochondria
phosphonium
mitochondria-targeting
membrane permeation
membrane potential
pH gradient
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2020.00783/full

Internet

https://www.frontiersin.org/article/10.3389/fchem.2020.00783/full

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