Aldosterone antagonists in monotherapy are protective against streptozotocin-induced diabetic nephropathy in rats.

Aldosterone antagonists in monotherapy are protective against streptozotocin-induced diabetic nephropathy in rats.

Angiotensin converting enzyme inhibitors (ACEi) and angiotensin II receptor blockers (ARB) are the standard clinical therapy of diabetic nephropathy (DN), while aldosterone antagonists are only used as adjuncts. Previously in experimental DN we showed that Na/K ATPase (NKA) is mislocated and angiote...

Full description

Bibliographic Details
Main Authors: Nora F Banki, Agota Ver, Laszlo J Wagner, Adam Vannay, Peter Degrell, Agnes Prokai, Renata Gellai, Lilla Lenart, Dorottya-Nagy Szakal, Eva Kenesei, Klara Rosta, Gyorgy Reusz, Attila J Szabo, Tivadar Tulassay, Chris Baylis, Andrea Fekete
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3386228?pdf=render

Internet

http://europepmc.org/articles/PMC3386228?pdf=render

Similar Items