A Novel Platform to Test In Vivo Single Gene Dependencies in t(8,21) and t(15,17) AML Confirms Zeb2 as Leukemia Target

A Novel Platform to Test In Vivo Single Gene Dependencies in t(8,21) and t(15,17) AML Confirms Zeb2 as Leukemia Target

The increased usage of high-throughput technologies in cancer research, including genetic and drug screens, generates large sets of candidate targets that need to be functionally validated for their roles in tumor development. Thus, reliable and robust in vivo model systems are needed to perform rev...

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Bibliographic Details
Main Authors: Giulia De Conti, Alicja M. Gruszka, Debora Valli, Andrea Umberto Cammarata, Matteo Righi, Massimiliano Mazza, Pier Giuseppe Pelicci
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Cancers
Subjects:
AML
mouse model
candidate genes
PML-RAR
AML1-ETO
Online Access:https://www.mdpi.com/2072-6694/12/12/3768

Internet

https://www.mdpi.com/2072-6694/12/12/3768

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